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Research Publications

Our laboratory is dedicated to studying the biophysical properties of lipid membranes and lipid-induced signaling pathways. Our research focuses on mycobacterial and eukaryotic biomembranes, both model and natural, with an emphasis on disease management and biotechnological applications. This section showcases some of our latest research publications.

2024

  1. Menon, A. P., Lee, T.-H., Aguilar, M.-I., & Kapoor, S. (2024). Decoding the role of mycobacterial lipid remodelling and membrane dynamics in antibiotic tolerance. Chemical Science, 15(45), 19084–19093. https://doi.org/10.1039/d4sc06618a

  2. Kumar, G., Agarwala, P. K., Srivatsav, A. T., Ravula, A., Ashmitha, G., Balakrishnan, S., Kapoor, S., and Narayan, R.  (2024). Identification and Benchmarking of Myokinasib-II as a Selective and Potent Chemical Probe for Exploring MLCK1 Inhibition. ACS Publications. https://doi.org/10.1021/acschembio.4c00336.s001

  3. Mathew, L. and Kapoor, S. (2024). Methods for studying fusion of bacterial extracellular vesicles with intact bacteria and host cells. Methods in Molecular Biology, vol 2843. https://doi.org/10.1007/978-1-0716-4055-5_8

  4. Srivatsav, A. T., Liang, K., Jaworek, M. W., Dong, W., Matsuo, T., Grélard, A., Peters, J., Winter, R., Duan, M., & Kapoor, S. (2024). Residual Membrane Fluidity in Mycobacterial Cell Envelope Layers under Extreme Conditions Underlines Membrane-Centric Adaptation. The Journal of Physical Chemistry. B, 128(28), 6838–6852. https://doi.org/10.1021/acs.jpcb.4c02469

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2023

  1. Agarwala, P. K., Nie, S., Reid, G. E., & Kapoor, S. (2023). Global lipid remodelling by hypoxia aggravates migratory potential in pancreatic cancer while maintaining plasma membrane homeostasis. Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids, 1868(12). https://doi.org/10.1016/j.bbalip.2023.159398 

  2. Srivatsav, A. T., & Kapoor, S. (2023). Biophysical Interaction Landscape of Mycobacterial Mycolic Acids and Phenolic Glycolipids with Host Macrophage Membranes. ACS Appl Bio Mater, 6(12), 5555-5562. https://doi.org/10.1021/acsabm.3c00748

  3. Dasgupta, A., Gangai, S., Narayan, R., & Kapoor, S. (2023). Mapping the Lipid Signatures in COVID-19 Infection: Diagnostic and Therapeutic Solutions. J Med Chem. https://doi.org/10.1021/acs.jmedchem.3c01238 

  4. Adhyapak, P., Liang, K., Duan, M., & Kapoor, S. (2023). Effect of Host Cholesterol on the Membrane Dynamics of Outer Membrane Lipids of Mycobacteria. Chem Asian J, e202300697. https://doi.org/10.1002/asia.202300697 

  5. Agarwala, P. K., Nie, S., Reid, G. E., & Kapoor, S. (2023). Global lipid remodelling by hypoxia aggravates migratory potential in pancreatic cancer while maintaining plasma membrane homeostasis. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1868(12), 159398. https://doi.org/10.1016/j.bbalip.2023.159398 

  6. Mishra, M., Gupta, A. D., Dadhich, R., Ahmad, M. N., Dasgupta, A., Chopra, S., & Kapoor, S. (2023). Mycobacterial lipid-derived immunomodulatory drug- liposome conjugate eradicates endosome-localized mycobacteria. J Control Release, 360, 578-590. https://doi.org/10.1016/j.jconrel.2023.07.013

  7. Mathew, L., Verma, D. K., Liang, K., Duan, M., Dadhich, R., & Kapoor, S. (2023). Fusion Landscape of Mycobacterial Envelope-Derived Lipid Vesicles with Intact Bacteria Dictates High Intracellular Drug Retention. ACS Appl Bio Mater, 6(8), 3066-3073. https://doi.org/10.1021/acsabm.3c00286 

  8. Kumar, G., & Kapoor, S. (2023). Targeting mycobacterial membranes and membrane proteins: Progress and limitations. Bioorg Med Chem, 81, 117212. https://doi.org/10.1016/j.bmc.2023.117212 

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2022

  1. Dadhich, R., Kapoor, S*. (2022) Lipidomic and Membrane Mechanical Signatures in Triple-Negative Breast Cancer: Scope for Membrane-Based Theranostics. Mol Cell Biochem. https://doi.org/10.1007/s11010-022-04459-4.

  2. Kotha, S., Solanke, B. U., Agarwala, P. K., & Kapoor, S. (2022). Design and synthesis of hetero-steroids via ring-closing metathesis: Biological studies towards in vitro anticancer activity. Steroids, 188, 109119. https://doi.org/10.1016/j.steroids.2022.109119

  3. Adhyapak, P., Dong, W., Dasgupta, S., Dutta, A., Duan, M., & Kapoor, S. (2022). Lipid clustering in mycobacterial cell envelope layers governs spatially resolved solvation dynamics. Chemistry – An Asian Journal, 17(11). https://doi.org/10.1002/asia.202200146 

  4. Menon, A. P., Dong, W., Lee, T.-H., Aguilar, M.-I., Duan, M., & Kapoor, S. (2022). Mutually exclusive interactions of Rifabutin with spatially distinct mycobacterial cell envelope membrane layers offer insights into membrane-centric therapy of infectious diseases. ACS Bio Med Chem Au. https://doi.org/10.1021/acsbiomedchemau.2c00010

  5. Mishra, M., & Kapoor, S. (2022). Multifaceted roles of mycobacterium cell envelope glycolipids during host cell membrane interactions. Biology of Mycobacterial Lipids, 105–131. https://doi.org/10.1016/b978-0-323-91948-7.00004-x

  6. Modak, B., Girkar, S., Narayan, R., & Kapoor, S. (2022). Mycobacterial membranes as actionable targets for lipid-centric therapy in tuberculosis. Journal of Medicinal Chemistry, 65(4), 3046–3065. https://doi.org/10.1021/acs.jmedchem.1c01870

 

2021

  1. Agarwala, P. K., Aneja, R., & Kapoor, S. (2021). Lipidomic landscape in cancer: Actionable Insights for membrane‐based therapy and diagnoses. Medicinal Research Reviews, 42(2), 983–1018. https://doi.org/10.1002/med.21868

  2. Garlapati, C., Joshi, S., Turaga, R. C., Mishra, M., Reid, M. D., Kapoor, S., Artinian, L., Rehder, V., & Aneja, R. (2021). Monoethanolamine-induced glucose deprivation promotes apoptosis through metabolic rewiring in prostate cancer. Theranostics, 11(18), 9089–9106. https://doi.org/10.7150/thno.62724 

  3. Srivatsav, A. T., & Kapoor, S. (2021). The emerging world of membrane vesicles: Functional relevance, Theranostic avenues and tools for investigating membrane function. Frontiers in Molecular Biosciences, 8. https://doi.org/10.3389/fmolb.2021.640355

  4. Ghosh, I., Singh, R. K., Mishra, M., Kapoor, S., & Jana, S. S. (2020). Switching between blebbing and lamellipodia depends on the degree of nonmuscle myosin II activity. Journal of Cell Science. https://doi.org/10.1242/jcs.248732

  5. Saha, P., Kumari Agarwala, P., Dadhich, R., Adhyapak, P., Kapoor, S., & Madhavan, N. (2021). Ligand induced cuii transport restricts cancer and mycobacterial growth: Towards a plug‐and‐select ion channel scaffold. ChemBioChem, 22(8), 1424–1429. https://doi.org/10.1002/cbic.202000731

 

2020

  1. Kumar, G., Narayan, R*., Kapoor, S* (2020). Chemical Tools for Illumination of Tuberculosis Biology, Virulence Mechanisms, and Diagnosis. J. Med. Chem. 2020, 63, 24, 15308–15332

  2. Zhao, L., Rupji, M., Kapoor, S., Yang, C., Aneja, R (2020). Efficacy based ginger fingerprinting reveals potential antiproliferative analytes for triple negative breast cancer. Scientific Reports, 10(1),19182. 

  3. Dadhich, R., and Kapoor, S* (2020) Various Facets of Pathogenic Lipids in Infectious Diseases: Exploring Virulent Lipid-Host Interactome and Their Druggability. Journal of Membrane Biology 253(5), 399-423.

  4. Mishra, M., Dadhich, R., Mogha, P., and Kapoor, S*. (2020) Mycobacterium Lipids Modulate Host Cell Membrane Mechanics, Lipid Diffusivity, and Cytoskeleton in a Virulence-Selective Manner. ACS Infectious Diseases, 6(9), 2386-2399. doi/10.1021/acsinfecdis.0c00128.

  5. Mishra, M., Kapoor, S*. Modulation of host cell membrane nanoenvironment by mycobacterial glycolipids: Involvement of PI(4,5)P2 signaling lipid? (2020) Faraday Discussions. doi.org/10.1039/D0FD00051E.

  6. Dadhich, R., Mishra, M., Ning, S., Jana, S., Sarpe, VA., Mahato, J., Duan, M*. Kulkarni, SS*, Kapoor, S*. (2020) A virulence-associated lipid with distinct conformational attributes: Impact on lateral organization of host plasma membrane and signaling. ACS Chem. Biol. 15, 3, 740-750.

  7. Adhyapak, P., Srivatsav, A., Mishra, M., Singh, A., Narayan, R., Kapoor, S*. (2020) Dynamical Organization of Compositionally Distinct Inner and Outer Membrane Lipids of Mycobacteria. Biophysical Journal, 118, 1279-1291.

 

2019​

  1. Mishra, M., Adhyapak, P., Dadhich, R., Kapoor, S*. (2019) Dynamic Remodeling of the Host Cell Membrane by Virulent Mycobacterial Sulfoglycolipid-1. Scientific Reports. 9:12844.

  2. Adhyapak, P. and Kapoor, S*. (2019). Membrane Dynamics in Health and Disease: Impact on Cellular Signalling. J Membrane Biol. https://doi.org/10.1007/s00232-019-00087-0.

  3. Cromm, PM., Adihou, H., Kapoor, S., et al. (2019). Lipidated stapled peptides targeting the acyl binding protein UNC119. ChemBioChem, 20, 2987-2990.

  4. Friese, A., Kapoor, S., Schneidewind, T., Vidadala, S. R., Sardana, J., Brause, A., Förster, T., Bischoff, M., Wagner, J., Janning, P., Ziegler, S., & Waldmann, H. (2019). Chemical Genetics reveals a role of dctp pyrophosphatase 1 in Wnt Signaling. Angewandte Chemie International Edition, 58(37), 13009–13013. https://doi.org/10.1002/anie.201905977

  5. Garlapati, C., Joshi, S., Sahoo, B., Kapoor, S*., Aneja, R.* (2019). The persisting puzzle of racial disparity in triple negative breast cancer: looking through a new lens. Frontiers In Bioscience, 11, 75-88.

  6. Dadhich, R., Singh, A., Menon, AP., Mishra, M., C D Athul., Kapoor, S*. (2019). Biophysical characterization of mycobacterial model membranes and their interaction with rifabutin: Towards lipid-guided drug screening in tuberculosis. Biochimica et Biophysica Acta (BBA) - Biomembranes,1861, 1213-1227.

  7. Schneidewind, T., Kapoor, S., Garivet, G., Karageorgis, G., Narayan, R., Vendrell-Navarro, G., Antonchick, A. P., Ziegler, S., & Waldmann, H. (2019). The Pseudo Natural product myokinasib is a myosin light chain kinase 1 inhibitor with unprecedented chemotype. Cell Chemical Biology, 26(4). https://doi.org/10.1016/j.chembiol.2018.11.014

 

2018

  1. Aswin T. Srivatsav, Manjari Mishra, Shobhna Kapoor (2018) Small-Molecule Modulation of Lipid-Dependent Cellular Processes against Cancer: fats of the Gunpoint. BioMed Research International. ID 6437371. doi.org/10.1155/2018/6437371.

  2. Brand S., Roy S., Kapoor S., et. al. (2018) Combined Proteomic and In Silico Target Identification Reveal a New Role for 5-lipoxygenase in Developmental Signaling Pathways. Cell Chemical Biology  25, 1095-1106.

 

2017

  1. Kapoor, S., Sheremet, M., Schröder, P., Kumar, K., Ziegler, S., Waldmann, H. (2017). Small Molecules Inspired by the Natural Product Withanolides as Potent Inhibitors of Wnt Signaling. ChemBioChem. 18, 1797-1806.

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Publications from before joining IIT Bombay

2016

  1. Kapoor, S., Ziegler, S., Waldmann, H. (2016). Novel Approaches to Map Small Molecule-Target Interactions. Bioorganic and Medicinal Chemistry. 24, 3232-3245.

  2. Sperlich, B., Kapoor, S., Waldmann, H., Winter, H., and Weise, K. (2016). Regulation of K-Ras4B membrane binding by calmodulin. Biophysical Journal, 111, 113-122.

  3. Kapoor, S., and Winter, R. (2016). Pressure Perturbation: A Prime Tool to Study Conformational Substates and Volume Fluctuations of Biomolecular Assemblies. In: Molecular Science of Fluctuations towards Biological Functions. Springer. pp 29-64.

 

2015

  1. Luong, T.Q., Kapoor, S., and Winter, R. (2015). Pressure—A Gateway to Fundamental Insights into Protein Solvation, Dynamics and Function. ChemPhysChem. 16, 3555-3571. Cover Picture

  2. Kapoor, S., Fansa, E.K., Möbitz, S., Ismail, S.A., Winter, R., Wittinghofer, A., and Weise, K. (2015). Effect of the N-terminal Helix and Nucleotide Loading on the Membrane and Effector binding of Arl2/3. Biophysical Journal. 109, 1619-1629.

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2014

  1. Kapoor, S., Berghaus, M., Suladze, S., Prumbaum, D., Grobelny, S., Degen, P., Raunser, S., and Winter, R. (2014). Prebiotic Cell Membranes Survive Extreme Environmental Pressure Conditions.  Angew. Chem. Int. Ed. 53, 8397-8401.

  2. Georget, E., Kapoor, S., Winter, R., Reineke, K., Song, Y., Callanan, M., Ananta, E., Heinz, V., and Mathys, A. In Situ Investigation of Geobacillus Stearothermophilus Spore Germination and Inactivation Mechanisms under Moderate High Pressure. Food Microbiol. 41, 8-18.

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2013

  1. Kapoor, S., Werkmueller, A., Goody, R.S., Waldmann, H., and Winter, R. (2013). Pressure modulation of Ras-Membrane interactions and intervesicle transfer.  J. Am. Chem. Soc. 135, 6149-6156.

  2. Prigozhin, M.B., Liu, Y., Wirth, A.J., Kapoor, S., Winter, R., Schulten, K., and Gruebele, M. (2013) Misplaced Helix Slows Down Ultrafast Pressure-Jump Protein Folding. Proc. Natl. Acad. Sci. U.S.A. 110, 8087-8092.

  3. Weise, K., Huster, D., Kapoor, S., Triola, G., Waldmann, H., and Winter, R. (2013) Gibbs energy determinants of lipoprotein insertion into lipid membranes: The case study of Ras proteins. Faraday Discussions, 549-561.

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​2012

  1. Kapoor, S., Weise, K., Erlkamp, M., Triola, G., Waldmann, H., and Winter, R. (2012). The role of G-domain orientation and nucleotide state on the Ras isoform-specific membrane interaction. Eur. Biophys. J. 41, 801-813.

  2. Kapoor, S., Triola, G., Vetter, I.R., Erlkamp, M., Waldmann, H., and Winter, R. (2012). Revealing conformational substates of lipidated N-Ras protein by pressure modulation. Proc. Natl. Acad. Sci. U.S.A. 109, 460-465.

  3. Weise, K., Kapoor. S., Wekmüller, A., Möbitz, S., Zimmermann, G., Triola, G., Waldmann, H., and Winter, R. (2012) Dissociation of the K-Ras4B/PDEδ complex upon contact with lipid membranes: Membrane delivery instead of extraction. J. Am. Chem. Soc. 134, 11503-11510.

  4. Seeliger, J., Evers, F., Jeworrek, C., Kapoor. S., Weise, K., Andreetto, E., Tolan, M., Kapurniotu, A., and Winter, R. (2012) Cross-amyloid interaction of Aβ and IAPP at lipid membranes. Angew. Chem. Int. Ed. 51, 679-683.

  5. Barackov, I., Kapoor, S., Mause, A., Winter, R., Schembecker, G., and Burghoff, B. (2012) Investigation of structural changes of β-casein and lysozyme at the gas-liquid interface during foam fractionation. J. Biotech. 161, 138-146.

  6. Henke, S., Schneemann, A., Kapoor, S., Winter, R., and Fischer. RA. (2012). Zinc-1,4-benzenedicarboxylate-bipyridine frameworks - Linker functionalization impacts network topology during solvothermal synthesis. J. Mat. Chem. 22, 909-918.

 

2011

  1. Weise, K., Kapoor, S., Denter, C., Nikolaus, J., Opitz, N., Koch, S., Triola, G., Herrmann, A., Waldmann, H., and Winter, R. (2011) Membrane-Mediated Induction and Sorting of K-Ras Microdomain Signaling Platforms. J. Am. Chem. Soc. 133, 880-887. Cover Article

  2. Kapoor, S., Werkmuller, A., Denter, C., Zhai, Y., Markgraf, J., Weise, K., Opitz, N., and Winter, R. (2011). Temperature-pressure phase diagram of a heterogeneous anionic model biomembrane system: Results from a combined calorimetry, spectroscopy and microscopy study. Biochim. Biophys.Acta, Biomembr. 1808, 1187-1195. 

 

2010

  1. Kapoor, S., Girish, TS., Mandal, SS., Gopal, B., and Bhattacharyya, AJ. (2010). Inhibition of a protein tyrosine phosphatase using mesoporous oxides. J. Phys. Chem. B. 114, 3117–3121.

 

2009

  1. Kapoor, S., Hegde, R., and Bhattcharyya, AJ. (2009). Influence of Surface Chemistry of Mesoporous Alumina with Wide Pore Size Distribution on Controlled Release. J. Controlled Release. 140, 34–39.

  2. Kapoor, S., Mondal, SS., and Bhattacharyya, AJ. (2009). Structure and Function of Hemoglobin Confined Inside Silica Nanotubes. J. Phys. Chem. B. 113, 14189–14195. Cover article.

  3. Kapoor, S., and Bhattacharyya, AJ. (2009). Ultrasound–Triggered Controlled Drug Delivery and Biosensing Using Silica Nanotubes. J. Phys. Chem. C. 113, 7155–7163. 

  4. Das, SK., Kapoor, S., Yamada, H., and Bhattacharyya, AJ. (2009). Effects of Surface acidity and pore size of Mesoporous alumina on degree of loading and controlled release of Ibuprofen. Microporous and Mesoporous Materials 118, 267–272.

 

2008

  1. Argen, D., Stehr, M., Berthold, CL., Kapoor, S., Oehlmann, W., Singh, M., and Schneider, G. Three-dimensional Structure of Apo and Holo-I-Alanine Dehydrogenase from Mycobacterium Tuberculosis Reveal Conformational Changes upon Coenyzme Binding. J. Mol. Biol. 377, 1161-1173.

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